MyBioSource.com's MLH1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence, Immunohistochemistry, and Western Blot. The MLH1 Antibody was generated using COCA2, and MLH1 as the antigen and it reacts with Human.
Description
Background: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA
mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the
heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2